Benign esophageal strictures are a common problem in endoscopic practice. The predominant
symptom of patients is dysphagia. The initial treatment option for a benign esophageal
stricture is dilation. A subgroup of strictures, i. e., those that are long (> 2 cm),
tortuous, and have a narrow diameter, tend to recur and are therefore called refractory.
Temporary stent placement, either with a self-expanding metal stent (SEMS) or a self-expanding
plastic stent (SEPS), can be considered in these patients. The results obtained so
far are disappointing, with long-term clinical resolution of the stricture achieved
in less than 50 % of patients. This is mainly due to hyperplastic tissue ingrowth
or overgrowth (experienced with SEMS) and stent migration (SEPS). New stent designs
are therefore needed for this indication. Initial results show that biodegradable
stents have the promise to be useful for refractory benign esophageal strictures;
however, this promise needs to be further elucidated in future studies.
References
- 1
Homs M Y, Siersema P D.
Stents in the GI tract.
Expert Rev Med Devices.
2007;
4
741-752
- 2
Verschuur E ML, Steyerberg E W, Kuipers E J. et al .
Effect of stent size on complications and recurrent dysphagia in patients with esophageal
or gastric cardia cancer.
Gastrointest Endosc.
2007;
65
592-601
- 3
Verschuur E M, Repici A, Kuipers E J. et al .
New design esophageal stents for the palliation of dysphagia from esophageal or gastric
cardia cancer: a randomized trial.
Am J Gastroenterol.
2008;
103
304-312
- 4
Verschuur E M, Kuipers E J, Siersema P D.
Esophageal stents for malignant strictures close to the upper esophageal sphincter.
Gastrointest Endosc.
2007;
66
1082-1090
- 5
Siersema P D, Homs M YV, Haringsma J. et al .
Use of large-diameter metallic stents to seal traumatic nonmalignant perforations
of the esophagus.
Gastrointest Endosc.
2003;
58
356-361
- 6
Siersema P D.
Treatment options for esophageal strictures.
Nat Clin Pract Gastroenterol Hepatol.
2008;
5
142-152
- 7
Cwikiel W, Willén R, Stridbeck H. et al .
Self-expanding stent in the treatment of benign esophageal strictures: experimental
study in pigs and presentation of clinical cases.
Radiology.
1993;
187
667-671
- 8
Tan B S, Kennedy C, Morgan R. et al .
Using uncovered metallic endoprostheses to treat recurrent benign esophageal strictures.
AJR Am J Roentgenol.
1997;
169
1281-1284
- 9
Song H Y, Park S I, Jung H Y. et al .
Benign and malignant esophageal strictures: treatment with a polyurethane-covered
retrievable expandable metallic stent.
Radiology.
1997;
203
747-752
- 10
Song H Y, Park S I, Do Y S. et al .
Expandable metallic stent placement in patients with benign esophageal strictures:
results of long-term follow-up.
Radiology.
1997;
203
131-136
- 11
Lee J G, Hsu R, Leung J W.
Are self-expanding metal mesh stents useful in the treatment of benign esophageal
stenoses and fistulas? An experience of four cases.
Am J Gastroenterol.
2000;
95
1920-1925
- 12
Mukherjee S, Kaplan D S, Parasher G, Sipple M S.
Expandable metal stents in achalasia – is there a role?.
Am J Gastroenterol.
2000;
95
2185-2188
- 13
Fiorini A, Fleischer D, Valero J. et al .
Self-expandable metal coil stents in the treatment of benign esophageal strictures
refractory to conventional therapy: a case series.
Gastrointest Endosc.
2000;
52
259-262
- 14
Song H Y, Jung H Y, Park S I. et al .
Covered retrievable expandable nitinol stents in patients with benign esophageal strictures:
initial experience.
Radiology.
2000;
217
551-557
- 15
De Palma G D, Iovino P, Masone S. et al .
Self-expanding metal stents for endoscopic treatment of esophageal achalasia unresponsive
to conventional treatments. Long-term results in eight patients.
Endoscopy.
2001;
33
1027-1030
- 16
Wadhwa R P, Kozarek R A, France R E. et al .
Use of self-expandable metallic stents in benign GI diseases.
Gastrointest Endosc.
2003;
58
207-212
- 17
Cheng Y S, Li M H, Chen W X. et al .
Temporary partially-covered metal stent insertion in benign esophageal stricture.
World J Gastroenterol.
2003;
9
2359-2361
- 18
Conio M, Blanchi S, Filiberti R. et al .
A modified self-expanding Niti-S stent for the management of benign hypopharyngeal
strictures.
Gastrointest Endosc.
2007;
65
714-720
- 19
Mayoral W, Fleischer D, Salcedo J. et al .
Nonmalignant obstruction is a common problem with metal stents in the treatment of
esophageal cancer.
Gastrointest Endosc.
2000;
51
556-559
- 20
Repici A, Conio M, De Angelis C. et al .
Temporary placement of an expandable polyester silicone-covered stent for treatment
of refractory benign esophageal strictures.
Gastrointest Endosc.
2004;
60
513-519
- 21
Broto J, Asensio M, Vernet J M.
Results of a new technique in the treatment of severe esophageal stenosis in children:
poliflex stents.
J Pediatr Gastroenterol Nutr.
2003;
37
203-206
- 22
Evrard S, Le Moine O, Lazaraki G. et al .
Self-expanding plastic stents for benign esophageal lesions.
Gastrointest Endosc.
2004;
60
894-900
- 23
Karbowski M, Schembre D, Kozarek R. et al .
Polyflex self-expanding, removable plastic stents: assessment of treatment efficacy
and safety in a variety of benign and malignant conditions of the esophagus.
Surg Endosc.
2008;
22
1326-1333
- 24
García-Cano J.
Dilation of benign strictures in the esophagus and colon with the Polyflex stent:
a case series study.
Dig Dis Sci.
2008;
53
341-346
- 25
Barthel J S, Kelley S T, Klapman J B.
Management of persistent gastroesophageal anastomotic strictures with removable self-expandable
polyester silicon-covered (Polyflex) stents: an alternative to serial dilation.
Gastrointest Endosc.
2008;
67
546-552
- 26
Pennathur A, Chang A C, McGrath K M. et al .
Polyflex expandable stents in the treatment of esophageal disease: initial experience.
Ann Thorac Surg.
2008;
85
1968-1972
- 27
Holm A N, de la Mora Levy J G, Gostout C J. et al .
Self-expanding plastic stents in treatment of benign esophageal conditions.
Gastrointest Endosc.
2008;
67
20-25
- 28
Dua K S, Vleggaar F P, Santharam R. et al .
Removable self-expanding plastic esophageal stent as a continuous, non-permanent dilator
in treating refractory benign esophageal strictures: a prospective two-center study.
Am J Gastroenterol.
2008;
103
2988-2994
- 29
Freeman M L.
Bioabsorbable stents for gastrointestinal endoscopy.
Tech Gastrointest Endosc.
2001;
3
120-125
- 30
Goldin E, Fiorini A, Ratan Y. et al .
A new biodegradable and selfexpanding stent for benign esophageal strictures [abstract].
Gastrointest Endosc.
1996;
43
294
- 31
Fry S W, Fleischer D E.
Management of a refractory benign esophageal stricture with a new biodegradable stent.
Gastrointest Endosc.
1997;
45
179-182
- 32
Saito Y, Tanaka T, Andoh A. et al .
Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments
in patients with benign esophageal stenosis.
World J Gastroenterol.
2007;
13
3977-3980
- 33
Ramage J I, Rumalla A, Baron T H. et al .
A prospective, randomized, double-blind, placebo-controlled trial of endoscopic steroid
injection therapy for recalcitrant esophageal peptic strictures.
Am J Gastroenterol.
2005;
100
2419-2425
- 34
Hordijk M L, Siersema P D, Tilanus H W. et al .
Electrocautery therapy for refractory anastomotic strictures of the esophagus.
Gastrointest Endosc.
2006;
63
157-163
P. D. SiersemaMD, PhD
Department of Gastroenterology and Hepatology
University Medical Center Utrecht
Heidelberglaan 100
3584 CX, Utrecht
The Netherlands
Fax: +31-88-7555533
Email: p.d.siersema@umcutrecht.nl